' 
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
320 mg
356%
Calcium (from Calcium Carbonate)
36 mg
3%
Grape Seed Extract (Vitis vinifera) (min. 90% Total Polyphenols)
100 mg
†
Top Medical Research Studies
9
Vitamin C enhances blood clotting
Ascorbic acid improves thrombotic function of platelets during living donor liver transplantation by modulating the function of the E3 ubiquitin ligases c-Cbl and Cbl-b.
Highly relevant to blood clotting
We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
Read More
8
Calcium type affects clot risk
Thrombotic Complications Associated With Right Atrial Lines in Neonates and Infants Undergoing Cardiac Surgery. Is Calcium Chloride a Culprit?
High relevance to thrombotic outcomes
We explored the impact of different calcium infusions on clotting risks in neonates undergoing cardiac surgery. Our study involved analyzing data from 135 babies who received either calcium chloride or calcium gluconate during their treatment.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
The findings highlighted a significant concern: when using calcium chloride, the incidence of thrombotic events was notably higher compared to those treated with calcium gluconate. Specifically, the odds of experiencing a blood clot were over three times greater in patients given calcium chloride.
With an overall thrombus occurrence of 9.9%, we observed that only 4.6% of the group receiving calcium gluconate developed such complications compared to 15% in the calcium chloride group. The evidence suggests that switching from calcium chloride to calcium gluconate could potentially reduce the risk of harmful blood clots in these vulnerable patients.
Read More
8
Scurvy-related DVT treated with vitamin C
Pediatric scurvy case report: a novel presentation with deep vein thrombosis secondary to large bilateral spontaneous iliac subperiosteal hematomas.
Unique case linking DVT and scurvy
We explored a unique case of a 14-year-old boy with autism who presented with deep vein thrombosis (DVT) due to large bilateral subperiosteal hematomas caused by vitamin C deficiency, known as scurvy. This rare situation is noteworthy as scurvy is typically associated with other symptoms, but here it led to an unusual complication of DVT.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
Read More
Most Useful Reviews
9.5
Eased leg swelling
Helps with leg swelling and blood clots. I’ve had multiple blood clots with resulting edema. This product is extremely helpful for the pain and swelling, and I recommend it to everyone I know.
Read More
9.5
Lowers cholesterol
Does the job! This excellent product has significantly lowered my blood cholesterol from 220 to 150 in just a few months and triglycerides from 240 to 145.
Read More
8.8
Strengthens vessels
It acts as an antioxidant to render free radicals harmless, strengthens vascular walls and capillaries, combats high blood pressure and arterial hardening, facilitates healing for varicose veins and varicocele, and provides a blood-thinning effect while enhancing blood circulation.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
- All Researches
9
Vitamin C aids tendon healing
The effect of fibrin clot and C vitamin on the surgical treatment of Achilles tendon injury in the rat model✰.
Demonstrates vitamin C effectiveness
In our investigation, we looked at how vitamin C, in combination with a fibrin clot, influences the healing of Achilles tendon injuries in rats. We used 52 adult Wistar-Albino rats and divided them into four distinct groups to assess various treatments.
The results showed that vitamin C, when paired with fibrin clot, significantly improved tendon healing. Not only did it enhance the mechanical strength of the tendon, but it also led to better histological and biochemical outcomes, suggesting a more robust healing process. We noted increased levels of important growth factors in the groups treated with fibrin clot and vitamin C.
Importantly, the findings indicated that vitamin C plays a beneficial role in recovery, especially when combined with other treatment strategies. While further research may be necessary to fully understand its isolated effects, the data suggests that vitamin C is a valuable component in the healing bundle for Achilles tendon injuries.
The results showed that vitamin C, when paired with fibrin clot, significantly improved tendon healing. Not only did it enhance the mechanical strength of the tendon, but it also led to better histological and biochemical outcomes, suggesting a more robust healing process. We noted increased levels of important growth factors in the groups treated with fibrin clot and vitamin C.
Importantly, the findings indicated that vitamin C plays a beneficial role in recovery, especially when combined with other treatment strategies. While further research may be necessary to fully understand its isolated effects, the data suggests that vitamin C is a valuable component in the healing bundle for Achilles tendon injuries.
Read More
9
Vitamin C enhances blood clotting
Ascorbic acid improves thrombotic function of platelets during living donor liver transplantation by modulating the function of the E3 ubiquitin ligases c-Cbl and Cbl-b.
Highly relevant to blood clotting
We sought to understand how ascorbic acid, commonly known as vitamin C, impacts blood clotting during living donor liver transplantation (LDLT). In our study, we analyzed blood samples from 21 recipients before and after their surgeries.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
We employed a well-structured approach, using rotational thromboelastography (TEG) and western blot analysis to scrutinize fibrinolysis and the functionality of specific proteins involved in clotting. Blood samples were tested in three distinct groups, one receiving vitamin C, to see its effects on clot rigidity and fibrinolysis.
Our findings revealed that ascorbic acid notably reduced fibrinolysis, which refers to the breakdown of blood clots, and improved the rigidity of the clots formed. Additionally, we observed that levels of a protein called Cbl-b were higher in those receiving vitamin C, while another protein, c-Cbl, showed reduced phosphorylation. These functional changes might explain how vitamin C supports better clotting during surgeries.
This study indicates that vitamin C could be a beneficial treatment to consider during LDLT to manage hyperfibrinolysis, thus promoting better outcomes for patients undergoing these complex procedures.
Read More
9
Calcium aids rapid blood clotting
Zeolite firmly anchored regenerated cellulose aerogel for efficient and biosafe hemostasis.
Calcium's beneficial role in treatment
We explored the role of calcium in promoting blood coagulation using a new zeolite-embedded regenerated cellulose aerogel (Z-RCA). This innovative hemostatic agent was designed to minimize common issues seen with previous zeolite-based products, like heat-induced tissue damage and unwanted blood clotting elsewhere in the body.
Our results showed that this aerogel effectively absorbed blood while releasing calcium ions, which play a crucial role in the blood clotting process. By combining the properties of zeolite and the calcium-releasing ability of the aerogel, we found that Z-RCA not only facilitated quicker blood clotting but did so safely, with less risk of adverse effects.
In animal trials, we observed that Z-RCA stopped bleeding faster than existing options like Quikclot and notably reduced blood loss by over 62%. This combination of effectiveness and safety makes Z-RCA a promising solution for achieving efficient hemostasis during emergencies.
Our results showed that this aerogel effectively absorbed blood while releasing calcium ions, which play a crucial role in the blood clotting process. By combining the properties of zeolite and the calcium-releasing ability of the aerogel, we found that Z-RCA not only facilitated quicker blood clotting but did so safely, with less risk of adverse effects.
In animal trials, we observed that Z-RCA stopped bleeding faster than existing options like Quikclot and notably reduced blood loss by over 62%. This combination of effectiveness and safety makes Z-RCA a promising solution for achieving efficient hemostasis during emergencies.
Read More
8
Scurvy-related DVT treated with vitamin C
Pediatric scurvy case report: a novel presentation with deep vein thrombosis secondary to large bilateral spontaneous iliac subperiosteal hematomas.
Unique case linking DVT and scurvy
We explored a unique case of a 14-year-old boy with autism who presented with deep vein thrombosis (DVT) due to large bilateral subperiosteal hematomas caused by vitamin C deficiency, known as scurvy. This rare situation is noteworthy as scurvy is typically associated with other symptoms, but here it led to an unusual complication of DVT.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
During our investigation, we observed that after administering vitamin C replacement, the patient's condition improved significantly. Follow-up imaging showed that both the DVT and the hematomas resolved. This outcome suggests that vitamin C can potentially have a positive impact in cases where blood clots are related to underlying deficiencies.
However, we must clarify that while vitamin C treatment appeared beneficial in this specific situation, our findings are based on a single case. Thus, further research would be essential to understand its broader implications on DVT treatment and the role of vitamin C in blood clot scenarios.
Read More
8
Vitamin C reduces clotting factors
Vitamin C suppresses lipopolysaccharide-induced procoagulant response of human monocyte-derived macrophages.
Moderately relevant study findings
We explored how vitamin C influences blood clotting in response to inflammation, specifically focusing on how it affects certain proteins involved in this process. In our study, we tested vitamin C at clinically relevant doses within human monocyte-derived macrophages. This investigation involved examining its effects on tissue factor (TF) and Factor VII Activating Protease (FSAP), two key proteins that play a role in triggering blood clotting after exposure to lipopolysaccharide (LPS), which is often associated with infection and inflammation.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
Our findings showed that vitamin C can prevent the activation of a protein called NF-kB, which is crucial for the inflammatory response. It turns out that vitamin C not only reduces the DNA-binding activity of NF-kB but also decreases the expression of TF and FSAP, suggesting it can effectively modulate clots formed in response to inflammation. Overall, we observed that vitamin C offers promising benefits in altering pro-inflammatory and pro-coagulation processes.
This means that aside from being a potent antioxidant, vitamin C might also support cardiovascular health by reducing the risk factors associated with clot formation during inflammatory responses. While more research is needed to validate these effects fully, our study opens the door to the potential role of vitamin C in managing clot-related disorders linked to inflammation.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Eased leg swelling
Helps with leg swelling and blood clots. I’ve had multiple blood clots with resulting edema. This product is extremely helpful for the pain and swelling, and I recommend it to everyone I know.
9.5
Lowers cholesterol
Does the job! This excellent product has significantly lowered my blood cholesterol from 220 to 150 in just a few months and triglycerides from 240 to 145.
8.8
Strengthens vessels
It acts as an antioxidant to render free radicals harmless, strengthens vascular walls and capillaries, combats high blood pressure and arterial hardening, facilitates healing for varicose veins and varicocele, and provides a blood-thinning effect while enhancing blood circulation.
8.8
Improved vein strength
Good for blood vessel ageing and inflammation. My parents' vein valves were weakened due to ageing, but after consuming them, they have shown improvement. They are effective for varicose veins and ageing blood vessels.
8.8
Enhanced circulation
This product helps with blood circulation, making me feel healthy again, and also aids in collagen production. It is certainly a quality ingredient.
